Lynch syndrome is a hereditary cancer syndrome that increases a person’s risk of developing several different types of cancer, including uterine (endometrial) cancer. Myriad myRisk™ Hereditary Cancer uses next-generation sequencing technology to identify patients who may be at risk of disease.

Lynch syndrome, also called Hereditary Non-polyposis Colorectal Cancer (HNPCC) syndrome, is a hereditary cancer syndrome that increases a person’s risk of developing several different types of cancer, including uterine (endometrial) and colorectal cancer. Lynch syndrome is linked to mutations in the MLH1, MSH2, MSH6 or  PMS2 genes.1

In addition to uterine and colon cancer, people with Lynch syndrome are also at higher risk of developing:

  • Ovarian cancer
  • Stomach cancer
  • In addition, rarely, urinary/renal, pelvic, biliary tract, small bowel, pancreatic, and brain cancers

Some people may also develop sebaceous adenomas, which are noncancerous tumors of an oil-producing gland of the skin.

risk of cancer in patients with lynch syndrome mutations

Assessing Your Risk for Lynch Syndrome

Myriad offers genetic testing to determine whether you are a carrier of any of the gene mutations associated with Lynch syndrome. In order to assess your risk of carrying these mutations, your healthcare professional may ask you questions about your personal and family medical history. If you are identified as being at increased risk for Lynch syndrome, genetic testing provides the most accurate means of determining your risk of developing cancer.

To help you assess whether you may be benefit from hereditary cancer genetic testing, take the Myriad Hereditary Cancer Quiz. This quiz can help you get the information you need to discuss your risk of cancer with your healthcare professional and ask for further evaluation.

Risk Factors for Lynch Syndrome

Knowing your potential risk for Lynch syndrome can help you and your healthcare professional make better, more informed decisions about your health, before the onset of cancer or before a second cancer has had a chance to develop. Genetic testing for hereditary uterine cancer with the Myriad myRisk™ Hereditary Cancer test should be considered if:*

You:

  • Have had uterine cancer or colorectal before age 50.
  • Have had an abnormal MSI/IHC tumor test result (colorectal/uterine).
  • Have had two or more Lynch syndrome cancers** at any age.
  • Have had a Lynch syndrome cancer and one or more of your relatives has also had a Lynch syndrome cancer.**
  • Have a previously identified Lynch syndrome mutation in the family.

Your Family:

  • Has had two or more family members with a Lynch syndrome cancer,** one before the age of 50.
  • Has had three or more family members with a Lynch syndrome cancer** at any age.
  • Has a previously identified Lynch syndrome mutation in the family.

Using Hereditary Cancer Testing to Reduce Your Uterine Cancer Risk

If the Myriad myRisk Hereditary Cancer test confirms the presence of a MLH1, MSH2, MSH6 or PMS2 mutation, the following medical management options may help reduce cancer risk and may either possibly delay the onset of cancer or detect it at an earlier, more treatable stage:

  • Increased surveillance for uterine, colon and ovarian cancer, such as starting cancer screening at an earlier age or screening more frequently
  • Surgical management
  • Chemoprevention (risk-reducing medications)

*Assessment criteria are based on medical society guidelines.

**Lynch-associated cancers include colon, uterine/endometrial, gastric, ovarian, ureter/renal, pelvic, biliary tract, small bowel, pancreatic, brain and sebaceous adenomas.

Any discussion of medical management options is for general informational purposes only and does not constitute a recommendation.  While genetic testing and medical society guidelines provide important and useful information, all medical management decisions should be made based on consultation between each patient and his or her healthcare professional.

References

1. Giardello RM, Brensinger JD, Petersen GM. AGA technical review on hereditary colorectal cancer and genetic testing. Gastroenterology 2001;121:198-213.