5-FU Dose Optimization
PK-guided dosing of 5-FU for patients with colorectal cancer
OnDose is a simple blood test that helps oncologists to optimize infusional 5-FU therapy. OnDose provides the data for PK-guided dose adjustments of infusional 5-FU to help optimize dosing for patients with colorectal cancer.
- OnDose can be offered to CRC patients with early- or late-stage disease receiving 5-FU-based chemotherapy
- OnDose is a diagnostic assay for the quantitative determination of 5-FU levels in human plasma
- The assay relies on the quantification of plasma 5-FU area under the curve (AUC) levels by antibody detection and has >99% correlation with high-performance liquid chromatography (HPLC) methodology1
- Saam J, Critchfield GC, Hamilton SA, et al. Body Surface Area–based dosing of 5-Fluorouracil results in extensive interindividual variability in 5-Fluorouracil expo- sure in colorectal cancer patients on FOLFOX regimens [published online ahead of print May 30, 2011]. Clin Colorectal Cancer. doi:10.1016/j.clcc.2011.03.015.