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The following information for Family Members will appear as part of the MMT for a patient found to have a mutation in the MSH3 Monoallelic gene.
This patient's relatives are at risk for carrying the same mutation(s) and associated cancer risks as this patient. Cancer risks for females and males who have this/these mutation(s) are provided below.
Family members should talk to a healthcare provider about genetic testing. Close relatives such as parents, children, brothers and sisters have the highest chance of having the same mutation(s) as this patient. Other more distant relatives such as cousins, aunts, uncles, and grandparents also have a chance of carrying the same mutation(s). Testing of at-risk relatives can identify those family members with the same mutation(s) who may benefit from surveillance and early intervention.
This patient carries a single MSH3 mutation (monoallelic). This patient's relatives are at risk for carrying a single MSH3 mutation, or mutations in both copies of MSH3 (biallelic). Relatives who have inherited mutations in both copies of MSH3 have an increased risk for colorectal and possibly other cancers. Genetic testing may be appropriate for close family members to determine whether they are at an increased risk for colorectal and other cancers.