Biomarkers include those related to inflammation, cellular trafficking, tissue expansion, cartilage degradation and joint damage, and stromal activity and regulation.
“Multi-biomarker statistical models outperformed individual biomarkers at estimating disease activity. Biomarker-based scores were significantly correlated with DAS28-CRP and could discriminate patients with low vs. moderate/high clinical disease activity. Such scores were also able to track changes in DAS28-CRP and were significantly associated with both joint inflammation measured by ultrasound and damage progression measured by radiography.”
Centola M, et al. Development of a multi-biomarker disease activity test for rheumatoid arthritis. PLoS ONE. 2013; 8(4): e60635.
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