FOLR1/FRα SPONSORED TESTING PROGRAM
COMPANION DIAGNOSTIC TEST FOR OVARIAN CANCER

Informing treatment for your platinum-resistant ovarian cancer patients through immunohistochemistry staining

FOLR1/FRα SPONSORED TESTING PROGRAM
COMPANION DIAGNOSTIC TEST FOR OVARIAN CANCER

Informing treatment for your platinum-resistant ovarian cancer patients through immunohistochemistry staining

Folate receptor alpha (FRα) is a biomarker utilized to determine eligibility for ELAHERE® (mirvetuximab soravtansine-gynx)

Approximately 1 in 3 patients with platinum-resistant ovarian cancer will show FRα expression to qualify for therapy1. Eligibility for ELAHERE is defined as tumor tissue that shows ≥75% tumor cells staining at 2+/3+ intensity.

FOLR1 Ovarian Cancer IHC Testing Program

To support physicians in determining FOLR1/FRα status in their ovarian cancer patients, Myriad will offer FOLR1/FRα* testing through a sponsored testing program for patients with a diagnosis of epithelial ovarian cancer, fallopian tube, or primary peritoneal cancer.

*Full name = VENTANA FOLR1 (FOLR1-2.1) RxDx Assay

Patient Eligibility Criteria:

Eligible patients may receive one (1) FOLR1/FRα immunohistochemistry for ovarian carcinoma at no cost regardless of test results or treatment decision. Patients must meet all of the following criteria to be eligible:

  • Patient has ovarian cancer (including epithelial ovarian cancer, primary peritoneal cancer or primary fallopian tube cancer)
  • Patient lives and receives treatment in the United States or a US Territory
  • Patient does not have a known FRα expression from a previous test
  • Patient has not previously been tested under this program

Please note the program does not cover any other costs, including, but not limited to, office fees and biopsy fees. FOLR1 will be made available broadly to prescribers without regard to prescribing volumes or other commercial considerations.

To enroll your patient in the FOLR1 IHC Testing Program, download the FOLR1 test request form.

How to test with FOLR1/FRα sponsored testing program

FOLR1/FRα results in 7 days or less upon receipt of the sample

Provider completes the test request form

Provider completes the test request form

Myriad Genetics receives the TRF and sends a tumor specimen collection kit to the pathology lab

Myriad Genetics receives the TRF and sends a tumor specimen collection kit to the pathology lab

Tumor sample arrives at Myriad Genetics lab and FOLR1/FRα testing is performed

Tumor sample arrives at Myriad Genetics lab and FOLR1/FRα testing is performed

Results are sent to the ordering provider in the mail

Results are sent to the ordering provider in the mail

Tumor block is returned to the pathology lab immediately after result reporting
(slides will not be returned)

Tumor block is returned to the pathology lab immediately after result reporting
(slides will not be returned)

FOLR1/FRα is run on FFPE sample or tissue with 50-100 tumor nuclei present on 2 slide sections 4 microns thick, placed on unstained, unbaked, positively charged slides.

References:
  1. Matulonis UA, et al., Efficacy and Safety of Mirvetuximab Soravtansine in Patients With Platinum-Resistant Ovarian Cancer With High Folate Receptor Alpha Expression: Results From the SORAYA Study. J Clin Oncol. 2023 Jan 30:JCO2201900. doi: 10.1200/JCO.22.01900. Epub ahead of print. PMID: 36716407.

Sponsored by
Immunogen