HOXB13 gene

Associated Syndrome Name: HOXB13-associated Cancer Risk (Men only)

HOXB13 Summary Cancer Risk Table

Cancer Genetic Cancer Risk
ProstateHigh Risk

HOXB13 gene Overview

HOXB13-associated Cancer Risk (Men only) 1, 2, 3, 4, 5
  • Men with the HOXB13 variant identified in this individual have been shown to have a greatly increased risk for prostate cancer. Risks appear to be highest in men with a family history of prostate cancer.
  • All of the studies to date have focused on men of European ancestry, so there is not enough evidence yet to know if this variant in HOXB13 leads to an increased risk for prostate cancer in men of other ancestries.
  • Some studies have shown that men with this variant in HOXB13 are more likely to be diagnosed with prostate cancer at younger ages than men in the general population.
  • At this time there are no established cancer risks for women with this variant or other variants in HOXB13.
  • Although there are high cancer risks for men with this variant in HOXB13, there may be interventions that can reduce these risks. Guidelines from the Philadelphia Prostate Cancer Consensus Conference are listed below. Since it is likely that these guidelines will change as we learn more about the cancer risks associated with this variant in HOXB13, it may be appropriate to interpret these results in consultation with cancer genetics professionals who have expertise in this emerging area of knowledge.

HOXB13 gene Cancer Risk Table

Cancer Type Age Range Cancer Risk Risk for General Population
ProstateTo age 801, 2, 3, 4, 622%-52%10.1%

HOXB13 Cancer Risk Management Table

The overview of medical management options provided is a summary of professional society guidelines. The most recent version of each guideline should be consulted for more detailed and up-to-date information before developing a treatment plan for a particular patient.

This overview is provided for informational purposes only and does not constitute a recommendation. While the medical society guidelines summarized herein provide important and useful information, medical management decisions for any particular patient should be made in consultation between that patient and his or her healthcare provider and may differ from society guidelines based on a complete understanding of the patient’s personal medical history, surgeries and other treatments.

Cancer Type Procedure Age to Begin Frequency
(Unless otherwise indicated by findings)
ProstateRecommend prostate cancer screening.5, 740 years, or 10 years younger than the earliest prostate cancer diagnosis in the familyAnnually, or adjusted based on results from first PSA screen

Information for Family Members

The following information for Family Members will appear as part of the MMT for a patient found to have a mutation in the HOXB13 gene.

This patient's relatives are at risk for carrying the same mutation(s) and associated cancer risks as this patient. Cancer risks for females and males who have this/these mutation(s) are provided below.

Family members should talk to a healthcare provider about genetic testing. Close relatives such as parents, children, brothers and sisters have the highest chance of having the same mutation(s) as this patient. Other more distant relatives such as cousins, aunts, uncles, and grandparents also have a chance of carrying the same mutation(s). Testing of at-risk relatives can identify those family members with the same mutation(s) who may benefit from surveillance and early intervention.

At this time, there are no known cancer risks for women due to mutations in HOXB13.


  1. Witte JS, et al. HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease. Cancer Epidemiol Biomarkers Prev. 2013 22:675-80. PMID: 23396964.
  2. Stott-Miller M, et al. HOXB13 mutations in a population-based, case-control study of prostate cancer. Prostate. 2013 73:634-41. PMID: 23129385.
  3. Beebe-Dimmer JL, et al. The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies. Cancer Epidemiol Biomarkers Prev. 2015 24:1366-72. PMID: 26108461.
  4. Cai Q, et al. Germline HOXB13 p.Gly84Glu mutation and cancer susceptibility: a pooled analysis of 25 epidemiological studies with 145,257 participates. Oncotarget. 2015 6:42312-21. PMID: 26517352.
  5. Giri VN, et al. Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019. J Clin Oncol. 2020 38:2798-2811. PMID: 32516092.
  6. SEER*Explorer: An interactive website for SEER cancer statistics [Internet]. Surveillance Research Program, National Cancer Institute. [Cited 2020 Sep 14]. Available from https://seer.cancer.gov/explorer/.
  7. Carroll PR, et al. NCCN Clinical Practice Guidelines in Oncology®: Prostate Cancer Early Detection. V 2.2021. July 14. Available at https://www.nccn.org.
Last Updated on 29-Sep-2022