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Anna, a Myriad Oncology patient, who has used MyRisk® Hereditary Cancer test

MyRisk® WITH RISKSCORE® Hereditary Cancer Test

The complete solution for hereditary cancer risk assessment and care planning

MyRisk® Hereditary Cancer Test evaluates 48 genes associated with hereditary cancer risk to identify genetic changes in patients with a family history of certain cancers, empowering healthcare providers to personalize care plans and help prevent cancer.

Make confident decisions with definitive answers from MyRisk.

Your first step toward personalized cancer prevention

For patients with a family history of certain cancers, hereditary cancer testing is essential to identify whether they are at an increased risk of developing specific types of cancer. 1 in 4 patients without cancer meet criteria for germline genetic testing.1

For people with a history of cancer, MyRisk identifies hereditary cancer syndromes associated with an increased risk of a second cancer, providing information to guide risk management decisions and facilitate family risk assessment.

1 in 4

women without cancer qualify for germline genetic testing1

Image showing the Myriad Oncology MyRisk test kit

Empower more patients with comprehensive cancer risk assessment

MyRisk with RiskScore is a powerful tool that empowers you and your patients to make more informed decisions to help prevent breast cancer or diagnose it at an earlier, more treatable stage.

  • Provides each patient with a comprehensive, personalized assessment of the five-year risk and remaining lifetime risk of developing cancer by combining personal and family history with breast cancer genetic risk markers and ancestry genetic markers
  • First and industry-leading comprehensive breast cancer risk assessment that includes breast density, clinical factors, and a unique polygenic risk score validated with outcomes data from >130,000 patients across all ancestries2-4
Graphic showing different components that make up the MyRisk® with RiskScore assessment tool

MyRisk with RiskScore brings clarity and confidence to cancer risk assessment

  • MyRisk with RiskScore offers improved risk stratification that is two times more predictive of breast cancer risk than Tyrer-Cuzick alone, empowering you and your patients to make informed, proactive decisions to help prevent cancer or detect it early, when treatment is most effective2
  • Over half of patients who test negative for a hereditary cancer syndrome will have a change in medical management due to their family history of cancer and/or their RiskScore5

Graph depicting a x2 increase in the predictive accuracy of breast cancer risk scores using MyRisk than Tyrer-Cuzick alone

Chart showing MyRisk definitively classifies up 63% of variants other labs may not

Accurate testing that goes beyond patients’ initial test results

Myriad is the industry leader in variant classification and reclassification. We use proprietary variant classification tools, including RNA testing and other cutting-edge technology, to provide comprehensive, clinically actionable and accurate results.

Reducing uncertainty for more patients

MyRisk offers the industry’s lowest reported rates of BRCA1/2 variants of uncertain significance (VUS) of <1.0%.6,7

Lifetime Classification Commitment

Myriad continuously re-evaluates VUS and sends amended reports whenever a patient’s result is reclassified a clinically significant.

Make confident risk management decisions with definitive answers

Every MyRisk test report provides a personalized assessment of a patient’s hereditary cancer risk, providing healthcare providers and patients with clear information to make informed decisions about managing cancer risk.

How to test with MyRisk

Myriad offers several MyRisk ordering options to better serve your patients and your practice, including portals for online ordering and options for sending MyRisk test kits directly to your patients’ homes.

Anna, a Myriad Oncology patient, who has used MyRisk® Hereditary Cancer test feeling empowered as she is working

Optimize your practice with Myriad Oncology’s workflow solutions

Myriad offers simplified workflow solutions that are customizable to your practice, saving staff time and reducing administrative burden.

  • Resources and support to help implement a Breast Cancer Risk Assessment Program
  • Tools to help identify patients who meet germline testing guidelines to inform treatment decisions
  • Pre- and post-test education as live, point-of-care sessions with a board-certified Genetic Counselor
  • Easy ordering options including paper, online, virtual, and EMR
  • Transparent pricing with personalized cost estimates, financial assistance, and other affordability options including direct pay
  • Results available on average 14 days from sample receipt
  • Comprehensive, clear, and easy-to-follow results so you can focus on patient treatment

Real expert support

First-class support from our team of board-certified genetic counselors gives you on-demand access to the information you need for every patient, every test, every time.

Workflows

Workflow solutions allow for simple integration of Myriad’s tests into routine clinical care and help patients better understand and benefit from their results. 

MyRisk Patient Story

Forging a path forward

Lisa’s mom’s battle with breast cancer inspired her to get genetic testing and make a life-saving choice. Her story is a testament to courage and resilience.

Image showing Myriad Oncology’s portfolio of germline and tumor genomic test kits

One simple order. Comprehensive results.

With Myriad Oncology, you can receive comprehensive results for germline testing, tumor genomic profiling and companion diagnostic options in one single ordering experience, getting clear, fast answers for your patients.

What to expect with every MyRisk test

Actionable

MyRisk offers clinically actionable results and personalized medical management guidance to inform confident patient care.

Affordable

Myriad is committed to providing patients with access to accurate and affordable genetic results through extensive coverage with most insurance plans and financial assistance programs. 

Accurate

Myriad believes in providing the most accurate and highest quality tests for patients. From hereditary cancer to precision medicine, our tests are designed to give clinicians and patients the most accurate answer possible. 

MyRisk resources

References:

  1. DeFrancesco MS, Waldman RN, Pearlstone MM, et al. Hereditary Cancer Risk Assessment and Genetic Testing in the Community-Practice Setting. Obstet Gynecol. 2018;132(5):1121-1129.
  2. Mabey B, Hughes E, Kucera M, et al. Validation of a clinical breast cancer risk assessment tool combining a polygenic score for all ancestries with traditional risk factors. Genet Med. 2024;26(7):101128.
  3. Hughes E, Wagner S, Pruss D, et al. Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition. JCO Precis Oncol. 2022;6:e2200084.
  4. Hughes E, Probst B, Pederson HJ, et al. A breast cancer (BC) risk model incorporating Tyrer-Cuzick version 8 (TCV8) and a polygenic risk score (PRS) for diverse ancestries. J Clin Oncol. 2022;40(16_suppl):557-557.
  5. Myriad internal data based on MyRisk tests reported between 09/01/2021 and 02/01/2023 ordered for unaffected patients by OBGYN & Primary Care healthcare providers.
  6. Gradishar WJ, et al. Clinical variant classification: a comparison of public databases and a commercial testing laboratory. The Oncologist. 2017;22(7):797–803. doi:10.1634/theoncologist.2016-0431.
  7. Mundt E, Iorg G. Driving Down the Rate of Variants of Uncertain Significance as the Myriad myRisk® Multigene Panel Grows [White paper]. Myriad Genetics. 2020.
  8. Internal data on file at Myriad Genetics, Inc.

Myriad Genetics, MyRisk, Precise Tumor, MyChoice, Prolaris, BRACAnalysis CDx, RiskScore, and their respective logos, are registered trademarks of Myriad Genetics, Inc. and its subsidiaries in the United States and other jurisdictions. EndoPredict and the EndoPredict logo are either trademarks or registered trademarks of Eurobio Scientific.