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Prequel®
Prenatal Screen with AMPLIFY™ Technology

Early genetic insights into a baby’s development

Designed for everyone, regardless of ancestry or BMI, Myriad’s Prequel non-invasive prenatal screen can determine if a pregnancy is at an increased risk for a wide variety of chromosomal conditions like Down, Edwards or Patau syndromes, and even provide the predicted sex of the baby.

Prequel®
Prenatal Screen with AMPLIFY™ Technology

Early genetic insights into a baby’s development

Designed for everyone, regardless of ancestry or BMI, Myriad’s Prequel non-invasive prenatal screen can determine if a pregnancy is at an increased risk for a wide variety of chromosomal conditions like Down, Edwards or Patau syndromes, and even provide the predicted sex of the baby.

Prequel Test Kit

Prenatal genetic screening to help patients prepare

Prequel is the only NIPS with revolutionary AMPLIFY technology that increases fetal fraction for everybody, including patients with high BMI.

Why screen with Prequel?

Screen 99.9% of all patients

Prequel provides results to >99.9% of patients. Our advanced science and technology works for any expectant parent regardless of age, ancestry, or BMI, including those with twin and IVF pregnancies.1,2

Lowest screening failure rate

By delivering the lowest screening failure rate in the industry, Prequel lowers the chance of needing a repeat test or an unnecessary invasive diagnostic procedure.3

Clear results, next steps, and support

Prequel results deliver clarity of a patient’s true risk with individualized positive-predictive-values (PPV) and residual-risk estimates to help inform next steps. All results include on-demand access to our board-certified genetic counselors to ensure prenatal screening results are understood.

plays Prequel prenatal screen - Patient education videolightbox

Clear prenatal screening results to inform patients and clinicians

Every Prequel Prenatal Screen provides clear, user-friendly results and access to board-certified genetic counselors for post-test education and counseling.

  • Clear, personalized risk of serious conditions

    Prequel reports include results for each chromosome condition screened, including trisomies, sex chromosomes, microdeletions and expanded aneuploidies. Results include screening methodology and a patient-specific risk using the test’s positive predictive value (PPV) for positive test results, or residual risk for negative results.

    View sample report

  • Detailed information for detected conditions

    Each detected condition includes a detailed summary, including recent and relevant references to help clinicians personalize and guide care.

    View conditions

  • Reveal predicted fetal sex

    For interested patients, Prequel results can also provide the predicted sex of a baby for singleton or twin pregnancies.

Guide informed planning and preparation

Prequel’s results help clinicians guide care and empower patients to take action to make the best decision for their family.

Explore different options such as:

Consulting with specialists

Knowing if a child requires a certain type of care before birth means you can involve the right kind of specialists long before delivery.

Finding the right place to deliver

Seek out a specialized facility that is equipped to manage newborns with chromosome conditions.

Seeking support

Guide your patients to talk with one of our board-certified genetic counselors or work with a support group to understand what could lie ahead.

Prequel patient story

Meet Hannah and family

Hear how non-invasive prenatal screening provided early insights into Hannah’s pregnancy and helped their family plan and prepare.

Prequel patient story

Meet Hannah and family

Hear how non-invasive prenatal screening provided early insights into Hannah’s pregnancy and helped their family plan and prepare.

Expert patient support at every step

From on-demand patient education to clear results reporting, Myriad offers seamless patient care throughout the entire Prequel screening process.

Prequel patients have unlimited access to one of Myriad’s 50+ board-certified genetic counselors to help understand prenatal screening and their results.

plays How Myriad's prenatal screening can benefit your patients videolightbox

How to test with the Prequel Prenatal Screen

Discuss Prequel screening with your patient and collect a patient blood sample

Discuss Prequel screening with your patient and collect a patient blood sample

Submit patient sample and completed Test Request Form to Myriad, or place an order in the Myriad Provider Portal

Submit patient sample and completed Test Request Form to Myriad, or place an order in the Myriad Provider Portal

Receive results in less than two weeks and review with patient

Receive results in less than two weeks and review with patient

Refer patients to schedule a consultation with Myriad’s board-certified genetic counselors

Refer patients to schedule a consultation with Myriad’s board-certified genetic counselors

Myriad offers several ordering options for our screens to better serve your patients and your practice, including portals for online ordering and mobile phlebotomy solutions for blood draws.

What to expect with every screen

Actionable

Every Prequel Prenatal Screen provides actionable results within two weeks to inform patient care decisions.

Affordable

Myriad is committed to providing patients with access to reliable and affordable genetic results through extensive coverage with most insurance plans and financial assistance programs.

Reliable

Myriad believes in providing the highest quality screens for patients. From prenatal screens to precision medicine, our products are designed to give providers and patients the most reliable answer possible

Related screens and tests

Foresight® Carrier Screen product signature

Foresight® Carrier Screen detects a couple’s risk of passing down serious, inheritable health conditions to their child to guide informed planning and preparation.

MyRisk™ product signature

MyRisk Hereditary Cancer Test is a multi-gene panel that helps to determine a patient’s risk by evaluating a number of hereditary cancer syndromes, with focus on 11 primary cancer sites.

Prequel resources

References:

  1. Hancock S, Ben-Shachar R, Adusei C, et al. Clinical experience across the fetal-fraction spectrum of a non-invasive prenatal screening approach with low test-failure rate. Ultrasound Obstet Gynecol. 2020;56(3):422-430. doi:10.1002/uog.21904.
  2. Muzzey D, Goldberg JD, Haverty C. Noninvasive prenatal screening for patients with high body mass index: Evaluating the impact of a customized whole genome sequencing workflow on sensitivity and residual risk. Prenat Diagn. 2020;40(3):333-341. doi:10.1002/pd.5603.
  3. Welker et al. High-throughput fetal fraction amplification increases analytical performance of noninvasive prenatal screening. Genet Med 23, 443–450 (2021).
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