About Hereditary Cancer Testing: Test Results

Discover more about what the results of a MyRisk™ test tell you and how you, in partnership with your healthcare provider, can use the results to tailor your strategies for managing risk.

What will the MyRisk™ test results tell me?

The MyRisk™ test report typically provides results in three main categories: Positive, Negative, or VUS (Variants of Uncertain Significance).

A positive result means our test found a variant in a specific gene that is associated with a higher risk of hereditary cancer. This may indicate an increased risk of developing cancers in the future and can be used to guide medical management (see below).

A negative result means that no genetic variants associated with an inherited cancer risk have been found in the genes that were analyzed. However, a negative result doesn’t mean someone cannot develop cancer during their lifetime. All appropriate cancer screening options should still be discussed with your healthcare provider.

A VUS result means that our test found a variant in a gene that has an unclear association with disease risk. More information about the variant is needed to better understand its association with cancer. VUS results are typically managed the same as negative results as most VUSs are not cancer causing. At Myriad, we regularly review VUSs and reclassify results when we know whether the variant is a negative (benign) genetic change or whether it is associated with cancer. When VUSs are reclassified, your healthcare provider is notified.

What will I do with the results?

Your results are a guide for you and your healthcare provider. Modifications to your medical management can be made, if necessary. When you know your results, you and your provider can implement strategies to decrease your risk of cancer and improve early cancer detection. This may look like starting cancer screenings at a younger age, getting enhanced or more frequent screenings, and employing risk reducing strategies.

We know it’s scary to think about, and sometimes these strategies include big decisions like risk-reducing surgery. This can be life-changing information, and most patients are grateful for the answers they receive so that they can take action in efforts to live longer, healthier lives.

If you think you’re ready to take the next step, click here to explore ways to test with your own healthcare provider or use online genetic testing options.

Have more questions? We’re here to help you every step of the way. Give our customer service team a call at 833-398-2137 or email [email protected].

Myriad Genetics Blog: Shelly Cummings

In recognition GC Awareness Day and GC Awareness Month, get to know Shelly Cummings, one of Myriad’s genetic counselors.