MYRIAD FOR RADIATION ONCOLOGISTS

Make confident decisions on ADT and radiation for prostate cancer

The Prolaris® Prostate Cancer Prognostic Test delivers actionable results to help radiation oncologists personalize androgen deprivation therapy (ADT) — predicting which patients truly benefit from it and who can safely pursue radiation therapy without hormone therapy for prostate cancer.1

Determine the best treatment for unfavorable intermediate risk prostate cancer patients

As a radiation oncologist treating men with localized prostate cancer, you face a critical question every day: Does this patient truly benefit from adding androgen deprivation therapy (ADT) to radiation therapy (RT)? Our data shows 1 in 2 men with unfavorable intermediate risk prostate cancer that received the Prolaris Test could avoid ADT.2

The Prolaris Test is the ONLY test that puts ADT benefit in numbers

The Prolaris Test helps you quickly make the most appropriate decision for each patient based on hard data, not assumptions.

  • Uniquely quantifies Absolute Risk Reduction (ARR) for RT + ADT vs RT alone to quickly measure the benefit of adding ADT1
  • Translates risk reduction to treatment impact by determining the Number Needed to Treat (NNT). For example, 4% ARR means you need to treat 25 patients for 1 to benefit from ADT1

Double validated for clinical action

The Prolaris Test empowers you to avoid overtreatment and prevent undertreatment — every patient, every plan:

Below the threshold, patients gain no significant benefit from intensifying treatment and can safely pursue single-modality treatment.2-4

Above the threshold, patients benefit from multi-modal treatment:

  • 5x reduction in 3-year metastasis risk (3% vs. 14.4%)5
  • 8% reduction in 10-year metastasis risk2

Prolaris - HCP Fairchild favorable intermediate utilitylightbox

Why order the Prolaris Test on your intermediate-risk patients?

Hear from radiation oncologist Dr. Fairchild as he discusses why he orders the Prolaris Test on both his favorable and unfavorable intermediate patients.

“For favorable intermediate-risk patients, active surveillance remains an option […] I typically omit hormone therapy based on Prolaris Test results and the risks associated with ADT.”

“The Prolaris Test does in fact, provide a very consistent and double validated model for the multimodal threshold, which helps in a general sense guide who you should routinely consider ADT for or who you should routinely consider omitting it. But at the moment, it’s the only biomarker that provides this highly personal risk estimate of absolute risk reduction so that the individual can really decide, regardless of threshold, whether using or omitting ADT is probably right for them.”

Dr. Jonathan Tward, MD, PhD, FASTRO, Huntsman Cancer Institute at the University of Utah

Tools to support your workflow

Myriad Oncology offers easy access to ordering, reporting, and collaboration resources designed to help radiation oncologists integrate genomic insights into daily practice.

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Understanding the Prolaris Test Report

The Prolaris Test results are designed with patients and providers in mind to quickly help answer pressing clinical questions, improving confidence in selecting the most appropriate management option.

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Order & Workflow Support

Access detailed ordering instructions, specimen handling guidelines, and pathology resources to streamline every step of the testing process.

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Prolaris Test Request Form (TRF)

Access the official Prolaris Biopsy Test Request Form to streamline orders and ensure complete documentation.

Take the next step in confident prostate cancer management

Connect with our team to learn more about integrating the Prolaris Test into your clinical workflow.

Download Physician Guide



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References:

  1. Tward JD, Lenz L, Gutin A, et al. Using the Cell-Cycle Risk Score to Predict the Benefit of Androgen-Deprivation Therapy Added to Radiation Therapy in Patients With Newly Diagnosed Prostate Cancer. JCO Precis Oncol. 2024;8:e2300722.
  2. Tward JD, Schlomm T, Bardot S, et al. Personalizing Localized Prostate Cancer: Validation of a Combined Clinical Cell-cycle Risk (CCR) Score Threshold for Prognosticating Benefit From Multimodality Therapy. Clin Genitourin Cancer. 2021;19(4):296-304.e3.
  3. Tward JD, Schlomm T, Bardot S, et al. Ability of the combined clinical cell-cycle risk score to identify patients that benefit from multi versus single modality therapy in NCCN intermediate and high-risk prostate cancer. J Clin Onc. 2020;38(6_suppl):346-346.
  4. Tward J, Lenz L, Flake DD II, et al. The Clinical Cell-Cycle Risk (CCR) Score Is Associated With Metastasis After Radiation Therapy and Provides Guidance on When to Forgo Combined Androgen Deprivation Therapy With Dose-Escalated Radiation. Int J Radiat Oncol Biol Phys. 2022;113(1):66-76.
  5. Hutten RJ, Odei B, Johnson SB, Tward JD. Validation of the Combined Clinical Cell-Cycle Risk Score to Prognosticate Early Prostate Cancer Metastasis From Biopsy Specimens and Comparison With Other Routinely Used Risk Classifiers. JCO Precis Oncol. 2024;8:e2300364.

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