Myriad Investor Day 2023 replay is now available. Watch now
Approximately 53,000 new cases of pancreatic cancer are diagnosed in the U.S. each year, some of which are caused by inherited gene mutations.1 Pancreatic cancer is associated with multiple hereditary cancer syndromes, but when it is the predominant cancer within a family, the most common known hereditary causes are mutations in the PALB2, BRCA2 or p16 genes.
Because pancreatic cancer can be seen in multiple hereditary cancer syndromes, it is it is important to consider a patient’s complete personal and family history when evaluating which genetic syndrome may be most likely. The Myriad MyRisk® gene panel test has the advantage of being able to test for many of the genes associated with several syndromes concurrently. Knowing the potential risk for hereditary pancreatic cancer can help you and your patient make better, more informed decisions about your patient’s health, before the onset of cancer or before a second cancer has had a chance to develop.
Genetic testing for hereditary pancreatic cancer should be considered if:*
You can use the Myriad Hereditary Cancer Quiz as a tool to help you identify patients who may benefit from hereditary cancer testing.
Get Your Custom Hereditary Cancer Quiz
If hereditary cancer testing confirms the presence of a PALB2, BRCA2 or other gene mutation, the following medical management options may help reduce cancer risk and either delay the onset of cancer, detect the disease at an earlier, more treatable stage or even prevent it.
Hereditary cancer gene panel testing results can assist you in developing personalized medical management plans that improve patient care by:
*Assessment criteria are based on scientific literature and individual medical society guidelines.
**Close refers to first- or second-degree relatives. First-degree relatives include parents, siblings and children. Second-degree relatives include grandparents, aunts/uncles and nieces/nephews.
†Any discussion of medical management options is for general informational purposes only and does not constitute a recommendation. While genetic testing and medical society guidelines provide important and useful information, all medical management decisions should be made based on consultation between each patient and his or her healthcare professional.
1. American Cancer Society. Pancreatic Cancer. Available at http://www.cancer.org/cancer/pancreaticcancer/detailedguide/pancreatic-cancer-key-statistics.
2. Jones S, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 2009;324(5924):217
3. Slater EP, et al. PALB2 mutations in European familial pancreatic cancer families. Clin Genet 2010;78:490-4
4. Tischkowitz MD, et al. Analysis of the gene coding for the BRCA2-interacting protein PALB2 in familial and sporadic pancreatic cancer. Gastroenterology 2009;137(3):1183-6.
5. Couch FJ, et al. The prevalence of BRCA2 mutations in familial pancreatic cancer. Cancer Epidemiol Biomarkers Prev 2007;16(2):342-6.
6. Hahn SA, et al. BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst 2003;95(3):214-21.
7. Murphy KM, et al. Evaluation of candidate genes MAP2K4, MADH4, ACVR1B and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Cancer Res 2002;62(13):3789-93.
8. Ozcelik H, et al. Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients. Nat Genet 1997;16(1):17-8.
9. Lal G, et al. Inherited predisposition to pancreatic adenocarcinoma: role of family history and germline p16, BRCA1 and BRCA2 mutations. Cancer Res 2000;60(2):409-16.
10. Ferrone CR, et al. BRCA Germline mutations in Jewish patients with pancreatic adenocarcinoma. J Clin Oncol 2009;27(3):433-8.
11. U.S. Preventive Services Task Force (USPSTF). Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility. Ann Intern Med 2005;143(5):355-61.
12. American Society of Breast Surgeons Official Statement, BRCA Genetic Testing for Patients With and Without Breast Cancer, 2006. Available at: http://www.breastsurgeons.org/statements/index.php
13. Lancaster JM, et al. Society of Gynecologic Oncologists (SGO) Education Committee Statement on Risk Assessment for Inherited Gynecological Cancer Predispositions. Gynecol Oncol 2007;107(2):159-62. Available at: http://www.sgo.org/WorkArea/showcontent.aspx?id=882
14. American College of Medical Genetics Foundation. Genetic Susceptibility to Breast and Ovarian Cancer: Assessment, counseling, and testing guidelines. 1999 (copyright is 2005). Available at: http://www.ncbi.nlm.nih.gov/books/NBK56955/
15. American College of Obstetricians and Gynecologists Committee on Practice Bulletins. Hereditary breast and ovarian cancer syndrome. Gynecol Oncol 2009;113(1):6-11. Available at: Hereditary breast and ovarian cancer syndrome.
16. Daly MB, et al. (2015) NCCN Clinical Practice Guidelines in Oncology, Genetic/Familial High-Risk Assessment Breast and Ovarian, V.2.2015. J Natl Compr Canc Netw Available t:http://www.nccn.org/professionals/physician_gls/f_guidelines.asp
17. Bevers TB, et al. (2015) NCCN Clinical Practice Guidelines in Oncology: Breast Cancer Screening and Diagnosis, BSCR-1-3, V.1.2015. J Natl Compr Canc Netw. Available at: http://www.nccn.org/professionals/physician_gls/f_guidelines.asp
Quick — name three diseases that affect humans. We bet you came up with some of the most well-known, such as heart disease, cancer, Alzheimer’s, and COVID-19. Those are all extremely common, affe...