More Than 30 Years as a Leader in Genetic Testing and Precision Medicine

The golden era of precision medicine is just beginning.

Myriad Genetics was founded in 1991, 10 years before the human genome was sequenced, making Myriad one of the first genomics companies in history. Today, Myriad is the pioneer and leader in genetic testing and precision medicine, offering innovative products that improve patients’ lives. These products include leading genetic tests for hereditary cancer, breast cancer prognostic, reproductive health, mental health and other diseases. We are excited about the future and remain committed to advancing the science of precision medicine as we develop more products to address unmet medical needs.

• Myriad’s genetic testing products are designed to assess an individual’s risk for developing disease so that action can be taken to prevent or delay its onset.
• Our diagnostic tests help in the early and accurate diagnosis of disease, when it is more treatable and survival rates are better.
• Our prognostic medicine products assess a patient’s risk of disease progression and recurrence, so that a healthcare professional knows how aggressively to treat the disease.
• Our companion diagnostic products identify a patient’s likelihood of responding to a particular therapy to ensure optimal treatment decisions.

Myriad and Gene Discovery

In conjunction with numerous collaborators from around the world, Myriad Genetics scientists discovered many important disease-causing genes, including:

• BRCA1 and BRCA2 genes associated with hereditary breast and ovarian cancer;
• p16 cell cycle control gene that increases the risk of developing a variety of cancers, notably melanoma;
• PTEN tumor suppressor gene that is involved in the development of many cancers;
• ELAC2 prostate cancer gene.

Myriad Developed the First Genetic Test to Assess Risk of Hereditary Breast and Ovarian Cancer

In 1996, Myriad introduced the first genetic test to assess risk of hereditary breast and ovarian cancer. This test, BRACAnalysis ^®, became the standard of care for determining a person’s risk of developing these hereditary cancers and has been followed by several other innovative genetic tests for breast, colon, pancreatic, prostate, ovarian and uterine cancers, as well as melanoma. To date, Myriad’s hereditary cancer tests have benefited millions upon millions of patients.

Advancing the Science of Genomics

Beginning in 2001, Myriad sequenced the rice genome, which revealed ways to increase crop yields, decrease pest infestation and potentially improve crop management. In addition, the genomes of the Pinot Noir grape, Golden Delicious apple and pufferfish were sequenced.

Myriad’s DNA Genotyping Capabilities Assisted in Identifying 9/11 Victims

In September 2001, Myriad provided genotyping assistance to the New York City Coroner’s Office to help identify the victims of the 9/11 attacks and bring closure to their families. In addition, Myriad scientists worked with the Scientific Advisory Board for the International Commission on Missing Persons to identify victims of the genocide in Bosnia.

Prolaris is the First Genetic Prognostic Test for Patients with Prostate Cancer

The launch of Prolaris in 2010 provided physicians with the first prognostic test that offers a direct measure of the molecular biology of an individual patient’s prostate cancer. By measuring the expression levels of genes involved in cancer cell proliferation, Prolaris is able to more accurately predict disease aggressiveness.

Global Expansion and Increased Reach

In 2012, Myriad expanded internationally with the opening of our laboratory in Munich, Germany. We currently have a presence in 128 countries: 16 in which we have direct subsidiaries and 112 countries in which we have 44 distributors on 6 continents. Our international corporate headquarters is located in Zurich, Switzerland, and we have sales operations in Paris, France; Madrid, Spain; Milan, Italy; Munich and Zurich. We believe that our robust portfolio of diagnostic tests will benefit patients worldwide by assisting healthcare professionals in guiding their healthcare decisions.

Diversifying Our Precision Medicine Portfolio

 

In 2013, Myriad launched MyRisk Hereditary Cancer, a multi-gene panel that identifies an elevated risk for eight hereditary cancers.

Advancing Precision Medicine

Myriad continued its pioneering work in personalized medicine with the launch of BRACAnalysis CDx in 2014. This test was the first and only FDA-approved companion diagnostic that helps identify patients with certain cancers who might benefit from treatment with AstraZeneca’s Lynparza™.